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Page 1
Serum PTH, PTH1R/ATF4 pathway, and the sRANKL/OPG system in bone as a new link between bone growth, cross-sectional geometry, and strength in young rats with experimental chronic kidney disease.
Sieklucka B, Pawlak D, Domaniewski T, Hermanowicz J, Lipowicz P, Doroszko M, Pawlak K. Sieklucka B, et al. Cytokine. 2021 Dec;148:155685. doi: 10.1016/j.cyto.2021.155685. Epub 2021 Aug 16. Cytokine. 2021. PMID: 34411988
The progression of chronic kidney disease (CKD) in children is associated with deregulated parathyroid hormone (PTH), growth retardation, and low bone accrual. ...In summary, the mild increase in endogenous PTH, its anabolic PTH1R/ATF4 axis and PTH-dependent alterat …
The progression of chronic kidney disease (CKD) in children is associated with deregulated parathyroid hormone (PTH), growth retardat …
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome.
Portales-Castillo I, Dean T, Cheloha RW, Creemer BA, Vilardaga JP, Savransky S, Khatri A, Jüppner H, Gardella TJ. Portales-Castillo I, et al. Commun Biol. 2023 Jun 2;6(1):599. doi: 10.1038/s42003-023-04966-0. Commun Biol. 2023. PMID: 37268817 Free PMC article.
Eiken syndrome is a rare disease of delayed bone mineralization caused by homozygous PTH1R mutations. Of the three mutations identified so far, R485X, truncates the PTH1R C-terminal tail, while E35K and Y134S alter residues in the receptor's amino-terminal extracell …
Eiken syndrome is a rare disease of delayed bone mineralization caused by homozygous PTH1R mutations. Of the three mutations identifi …
The pathophysiology of hypophosphatemia.
Ito N, Hidaka N, Kato H. Ito N, et al. Best Pract Res Clin Endocrinol Metab. 2024 Mar;38(2):101851. doi: 10.1016/j.beem.2023.101851. Epub 2023 Nov 30. Best Pract Res Clin Endocrinol Metab. 2024. PMID: 38087658 Review.
FGF23 related, B. primary tubular dysfunction, C. disturbance of vitamin D metabolism, and D. parathyroid hormone 1 receptor (PTH1R) mediated. Each group is further divided into its inherited form and acquired form. ...
FGF23 related, B. primary tubular dysfunction, C. disturbance of vitamin D metabolism, and D. parathyroid hormone 1 receptor (PTH1R) …
RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia.
Znorko B, Pawlak D, Oksztulska-Kolanek E, Domaniewski T, Pryczynicz A, Roszczenko A, Rogalska J, Lipowicz P, Doroszko M, Brzoska MM, Pawlak K. Znorko B, et al. Cytokine. 2018 Jun;106:19-28. doi: 10.1016/j.cyto.2018.03.002. Epub 2018 Mar 9. Cytokine. 2018. PMID: 29529595
Serum PTH and bone PTH1R/ATF4 expression was elevated in CKD-3 compared with other groups, and it positively correlated with femur weight, BMD, and the biomechanical properties of the femoral diaphysis reflecting cortical bone strength. ...A decrease in the RANKL/OPG ratio …
Serum PTH and bone PTH1R/ATF4 expression was elevated in CKD-3 compared with other groups, and it positively correlated with femur we …
Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation.
Zhai X, Mao C, Shen Q, Zang S, Shen DD, Zhang H, Chen Z, Wang G, Zhang C, Zhang Y, Liu Z. Zhai X, et al. Nat Commun. 2022 Oct 21;13(1):6276. doi: 10.1038/s41467-022-34009-x. Nat Commun. 2022. PMID: 36271004 Free PMC article.
The parathyroid hormone type 1 receptor (PTH1R), a class B1 G protein-coupled receptor, plays critical roles in bone turnover and Ca(2+) homeostasis. ...Here, we report the cryo-electron microscopy structures of PTH- and ABL-bound PTH1R-Gs complexes, adapting simila …
The parathyroid hormone type 1 receptor (PTH1R), a class B1 G protein-coupled receptor, plays critical roles in bone turnover and Ca( …
[Regulatory mechanism of calcium metabolism.].
Ozono K. Ozono K. Clin Calcium. 2017;27(4):483-490. Clin Calcium. 2017. PMID: 28336823 Review. Japanese.
Two major regulators to increase the serum calcium levels are parathyroid hormone(PTH)and vitamin D. PTH binds to the G protein coupling receptor, PTH1R, and increases intracellular cAMP levels. Impirement in the PTH signalling causes many diseases such as pseudohyp …
Two major regulators to increase the serum calcium levels are parathyroid hormone(PTH)and vitamin D. PTH binds to the G protein coupling rec …
Novel role of parathyroid hormone-related protein in the pathophysiology of the diabetic kidney: evidence from experimental and human diabetic nephropathy.
Romero M, Ortega A, Olea N, Arenas MI, Izquierdo A, Bover J, Esbrit P, Bosch RJ. Romero M, et al. J Diabetes Res. 2013;2013:162846. doi: 10.1155/2013/162846. Epub 2013 Jul 31. J Diabetes Res. 2013. PMID: 23984429 Free PMC article. Review.
Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function. ...Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be li …
Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where the …
Heterotrimeric G proteins in the control of parathyroid hormone actions.
Bastepe M, Turan S, He Q. Bastepe M, et al. J Mol Endocrinol. 2017 May;58(4):R203-R224. doi: 10.1530/JME-16-0221. J Mol Endocrinol. 2017. PMID: 28363951 Free PMC article. Review.
Parathyroid hormone (PTH) is a key regulator of skeletal physiology and calcium and phosphate homeostasis. It acts on bone and kidney to stimulate bone turnover, increase the circulating levels of 1,25 dihydroxyvitamin D and calcium and inhibit the reabsorption of phosphat …
Parathyroid hormone (PTH) is a key regulator of skeletal physiology and calcium and phosphate homeostasis. It acts on bone and kidney …
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
Daley EJ, Yoon SH, Reyes M, Bruce M, Brooks DJ, Bouxsein M, Potts JT, Kronenberg HM, Wein MN, Lanske B, Jüppner H, Gardella TJ. Daley EJ, et al. Endocrinology. 2022 Jul 1;163(7):bqac054. doi: 10.1210/endocr/bqac054. Endocrinology. 2022. PMID: 35460406 Free PMC article.
Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogues for their pharmacologic activities and potential therapeutic utility toward diseases of bone and mineral ion metabolism. Divergence, however, in the …
Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogues for their pharma …
Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.
Tao YX. Tao YX. Pharmacol Ther. 2006 Sep;111(3):949-73. doi: 10.1016/j.pharmthera.2006.02.008. Epub 2006 Apr 17. Pharmacol Ther. 2006. PMID: 16616374 Review.
Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990, significant progresses have been made in elucidating the pathophysiology of diseases caused by inactivating mutations of G protein-coupled receptors (GPCRs). This review aims to c …
Since the discovery of the first rhodopsin mutation that causes retinitis pigmentosa in 1990, significant progresses have been made in eluci …
44 results